αvβ3 -targeted nanoemulsions for tumor angiogenesis phenotyping with MRI and NIRF imaging
نویسندگان
چکیده
P. A. Jarzyna, L. H. Deddens, B. H. Kann, S. Ramachandran, C. Calcagno, W. Chen, A. Gianella, R. M. Dijkhuizen, A. W. Griffioen, Z. A. Fayad, and W. J. Mulder Translational and Molecular Imaging Institute, Radiology, Mount Sinai School of Medicine, New York, NY, United States, Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Amsterdam, Netherlands
منابع مشابه
Tumor angiogenesis phenotyping by nanoparticle-facilitated magnetic resonance and near-infrared fluorescence molecular imaging.
One of the challenges of tailored antiangiogenic therapy is the ability to adequately monitor the angiogenic activity of a malignancy in response to treatment. The α(v)β(3) integrin, highly overexpressed on newly formed tumor vessels, has been successfully used as a target for Arg-Gly-Asp (RGD)-functionalized nanoparticle contrast agents. In the present study, an RGD-functionalized nanocarrier ...
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